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PGH synthetase has two activities, the cyclooxygenase activity which introduces the 5-membered ring into the PUFA (polyunsaturated fatty acid), and another which introduces an endoperoxide and a hydroperoxide into the PUFA

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Daniele used to work in a rehab clinic and was doing all the recovery work the right way—but still, he says, the pain was enough to curtail his sporting life and even made climbing stairs difficult